{"id":88247,"date":"2021-09-27T20:35:06","date_gmt":"2021-09-27T18:35:06","guid":{"rendered":"https:\/\/pranoya.ro\/pranoya-toothpaste-clinical-trials\/"},"modified":"2024-08-24T12:58:29","modified_gmt":"2024-08-24T10:58:29","slug":"clinical-trials-toothpaste-pranoya","status":"publish","type":"page","link":"https:\/\/pranoya.ro\/en\/clinical-trials-toothpaste-pranoya\/","title":{"rendered":"Clinical trials of toothpaste PRANOYA"},"content":{"rendered":"

[vc_row][vc_column][vc_empty_space empty_h=”2″][\/vc_column][\/vc_row][vc_row unlock_row=”” row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ border_color=”color-465725″ border_style=”solid” shift_y=”0″ z_index=”0″ css=”.vc_custom_1601902043111{border-top-width: 1px !important;border-right-width: 1px !important;border-bottom-width: 1px !important;border-left-width: 1px !important;}”][vc_column column_width_percent=”100″ position_vertical=”middle” align_horizontal=”align_center” gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ border_color=”color-465725″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/2″][vc_custom_heading text_color=”color-465725″ text_size=”fontsize-131066″ text_weight=”400″ text_transform=”uppercase” text_height=”fontheight-357766″ uncode_shortcode_id=”203502″ text_color_type=”uncode-palette” subheading=”ISO 11609 Annex B”]RDA (RELATIVE DENTIN ABRASION)[\/vc_custom_heading][vc_single_image media=”90463″ media_width_percent=”50″ alignment=”center” uncode_shortcode_id=”134712″][\/vc_column][vc_column column_width_percent=”100″ position_vertical=”middle” align_horizontal=”align_center” gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/2″][vc_custom_heading text_color=”color-465725″ text_size=”fontsize-131066″ text_weight=”400″ text_transform=”uppercase” text_height=”fontheight-357766″]CONFIRMED STANDARDS AND METHODS[\/vc_custom_heading][vc_custom_heading text_color=”color-876287″ text_size=”fontsize-132385″ text_weight=”400″ text_height=”fontheight-357766″ uncode_shortcode_id=”443648″ text_color_type=”uncode-palette”]THE STUDY IS CONDUCTED, PROVEN AND COMPLIANT WITH ISO 11609 STANDARDS:<\/strong>
\nPurpose: <\/i>To use acellular samples of human dentin as a test substrate to determine the RDA of Product: PRANOYA Toothpaste for Cosmetic Dentistry and Natural Teeth against the ISO 11609 reference index (Annex B).
\nConclusion:<\/strong>
\n– The abrasivity of the PRANOYA toothpaste formulation evaluated in this study was well below the upper safe limit of ISO 11609.
\n– PRANOYA toothpaste formulation has passed ISO 11609 safety requirements.<\/p>\n

At 2000 stokes it has a low RDA, at 4000 stokes (3rd standard and latest version) it has an RDA of 104 (ideally 100).[\/vc_custom_heading][\/vc_column][\/vc_row][vc_row unlock_row=”” row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″][vc_column width=”1\/1″][\/vc_column][\/vc_row][vc_row unlock_row=”” row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ border_color=”color-465725″ border_style=”solid” shift_y=”0″ z_index=”0″ css=”.vc_custom_1601902043111{border-top-width: 1px !important;border-right-width: 1px !important;border-bottom-width: 1px !important;border-left-width: 1px !important;}”][vc_column column_width_percent=”100″ position_vertical=”middle” align_horizontal=”align_center” gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ border_color=”color-465725″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/2″][vc_custom_heading text_color=”color-465725″ text_size=”fontsize-131066″ text_weight=”400″ text_transform=”uppercase” text_height=”fontheight-357766″ uncode_shortcode_id=”757925″ text_color_type=”uncode-palette” subheading=”The study is accredited by RENAR and ILAC-MRA”]MICROBIOLOGICAL TEST[\/vc_custom_heading][\/vc_column][vc_column column_width_percent=”100″ position_vertical=”middle” align_horizontal=”align_center” gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/2″][vc_custom_heading text_color=”color-465725″ text_size=”fontsize-131066″ text_weight=”400″ text_transform=”uppercase” text_height=”fontheight-357766″]CONFIRMED STANDARDS AND METHODS[\/vc_custom_heading][vc_gallery el_id=”gallery-85457″ type=”carousel” medias=”83179,83180,83181,83182,83176,83183″ carousel_lg=”5″ carousel_md=”5″ carousel_sm=”3″ gutter_size=”3″ media_items=”media|nolink|original,icon” carousel_interval=”3000″ carousel_navspeed=”400″ carousel_loop=”yes” stage_padding=”0″ single_overlay_opacity=”50″ single_overlay_anim=”no” single_text_anim=”no” single_image_anim=”no” single_padding=”4″ single_border=”yes” title=”ISO”][\/vc_column][\/vc_row][vc_row unlock_row=”” row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″][vc_column width=”1\/1″][\/vc_column][\/vc_row][vc_row unlock_row=”” row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ border_color=”color-465725″ border_style=”solid” shift_y=”0″ z_index=”0″ css=”.vc_custom_1601902043111{border-top-width: 1px !important;border-right-width: 1px !important;border-bottom-width: 1px !important;border-left-width: 1px !important;}”][vc_column column_width_percent=”100″ position_vertical=”middle” align_horizontal=”align_center” gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ border_color=”color-465725″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/2″][vc_custom_heading text_color=”color-465725″ text_size=”fontsize-131066″ text_weight=”400″ text_transform=”uppercase” text_height=”fontheight-357766″ uncode_shortcode_id=”151852″ text_color_type=”uncode-palette” subheading=”Accredited laboratory”]CHALLENGE TEST[\/vc_custom_heading][vc_single_image media=”83194″ media_width_percent=”70″ alignment=”center” uncode_shortcode_id=”153055″][\/vc_column][vc_column column_width_percent=”100″ position_vertical=”middle” align_horizontal=”align_center” gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/2″][vc_custom_heading text_color=”color-465725″ text_size=”fontsize-131066″ text_weight=”400″ text_transform=”uppercase” text_height=”fontheight-357766″]CONFIRMED STANDARDS AND METHODS[\/vc_custom_heading][vc_single_image media=”83178″ media_width_percent=”20″ alignment=”center” uncode_shortcode_id=”365474″][\/vc_column][\/vc_row][vc_row unlock_row=”” row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″][vc_column width=”1\/1″][\/vc_column][\/vc_row][vc_row unlock_row=”” row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ border_color=”color-465725″ border_style=”solid” shift_y=”0″ z_index=”0″ css=”.vc_custom_1601902043111{border-top-width: 1px !important;border-right-width: 1px !important;border-bottom-width: 1px !important;border-left-width: 1px !important;}”][vc_column column_width_percent=”100″ position_vertical=”middle” align_horizontal=”align_center” gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ border_color=”color-465725″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/2″][vc_custom_heading text_color=”color-465725″ text_size=”fontsize-131066″ text_weight=”400″ text_transform=”uppercase” text_height=”fontheight-357766″ uncode_shortcode_id=”404937″ text_color_type=”uncode-palette” subheading=”Accredited laboratory”]PHYSICAL CHEMICAL TESTS[\/vc_custom_heading][vc_single_image media=”83194″ media_width_percent=”70″ alignment=”center” uncode_shortcode_id=”156344″][\/vc_column][vc_column column_width_percent=”100″ position_vertical=”middle” align_horizontal=”align_center” gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/2″][vc_custom_heading text_color=”color-465725″ text_size=”fontsize-131066″ text_weight=”400″ text_transform=”uppercase” text_height=”fontheight-357766″]CONFIRMED STANDARDS AND METHODS[\/vc_custom_heading][vc_custom_heading text_color=”color-876287″ text_size=”fontsize-132385″ text_weight=”400″ text_transform=”uppercase” text_height=”fontheight-357766″ uncode_shortcode_id=”128087″ text_color_type=”uncode-palette”]PB-155 ed.I of 02.05.2012 – CONFORMABLE<\/strong><\/em>
\nPB-234 ed. I of 03.10.2013r. – CONFORMABLE<\/strong><\/em>
\nBrookfield DVIII ultra – CONFORMABLE<\/strong><\/em>[\/vc_custom_heading][vc_single_image media=”83177″ media_width_percent=”20″ alignment=”center” uncode_shortcode_id=”118216″][\/vc_column][\/vc_row][vc_row unlock_row=”” row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″][vc_column width=”1\/1″][\/vc_column][\/vc_row][vc_row unlock_row=”” row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”2″ column_width_percent=”100″ border_color=”color-465725″ border_style=”solid” shift_y=”0″ z_index=”0″ css=”.vc_custom_1601902105870{border-top-width: 1px !important;border-right-width: 1px !important;border-bottom-width: 1px !important;border-left-width: 1px !important;}”][vc_column column_width_percent=”100″ position_vertical=”middle” align_horizontal=”align_center” gutter_size=”3″ overlay_alpha=”50″ border_color=”color-465725″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_custom_heading text_color=”color-465725″ text_size=”fontsize-131066″ text_weight=”400″ text_transform=”uppercase” text_height=”fontheight-357766″ uncode_shortcode_id=”108092″ text_color_type=”uncode-palette”]DERMATOLOGICAL COMPATIBILITY TEST[\/vc_custom_heading][vc_custom_heading text_color=”color-876287″ text_size=”fontsize-132385″ text_weight=”400″ text_height=”fontheight-357766″]THE STUDY IS CARRIED OUT, PROVED AND IN ACCORDANCE WITH THE STANDARDS:<\/strong>
\nRegulation of European Parliament of Council (EC) No. 1223\/2009 of 30 November 2009 on cosmetic products.<\/em><\/p>\n

Cosmetics Europe – The Personal Care Association (previously COLIPA) Guidelines \u201cProduct Test<\/em><\/p>\n

Guidelines for the Assessment of Human Skin Compatibility 1997<\/em><\/p>\n

Cosmetics Europe – The Personal Care Association (previously COLIPA) Guidelines for the Evaluation of the Efficacy of Cosmetic Products 2008.<\/em><\/p>\n

 <\/p>\n

The dermatological study was performed on a sample of 50 people<\/strong> of which 25 with a negative allergen history and 25 with a positive allergen history.<\/p>\n

Two assessments were made at 48 and 72 hours, respectively.<\/p>\n

The result of the study proved 0 (zero)<\/strong> allergenic reactions in all subjects tested.[\/vc_custom_heading][\/vc_column][\/vc_row][vc_row unlock_row=”” row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″][vc_column width=”1\/1″][\/vc_column][\/vc_row][vc_row unlock_row=”” row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”2″ column_width_percent=”100″ border_color=”color-465725″ border_style=”solid” shift_y=”0″ z_index=”0″ css=”.vc_custom_1601902105870{border-top-width: 1px !important;border-right-width: 1px !important;border-bottom-width: 1px !important;border-left-width: 1px !important;}”][vc_column column_width_percent=”100″ position_vertical=”middle” align_horizontal=”align_center” gutter_size=”3″ overlay_alpha=”50″ border_color=”color-465725″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_custom_heading text_color=”color-465725″ text_size=”fontsize-131066″ text_weight=”400″ text_transform=”uppercase” text_height=”fontheight-357766″ uncode_shortcode_id=”211674″ text_color_type=”uncode-palette”]STABILITY AND COMPATIBILITY IN VIEW OF DETERMINATION OF MINIMUM DURABILITY[\/vc_custom_heading][vc_custom_heading text_color=”color-876287″ text_size=”fontsize-132385″ text_weight=”400″ text_height=”fontheight-357766″]THE STUDY IS CARRIED OUT, PROOF AND IN ACCORDANCE WITH THE STANDARDS:<\/strong>
\nRegulation of European Parliament of Council (EC) No. 1223\/2009 of 30 November 2009 on cosmetic products.<\/em>
\n\u201cGuidelines on stability testing of cosmetic products, March 2004\u201d (CTFA)<\/em><\/p>\n

Strictly tested with fluctuations 70 days.<\/strong>[\/vc_custom_heading][\/vc_column][\/vc_row][vc_row unlock_row=”” row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″][vc_column width=”1\/1″][\/vc_column][\/vc_row][vc_row unlock_row=”” row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”2″ column_width_percent=”100″ border_color=”color-465725″ border_style=”solid” shift_y=”0″ z_index=”0″ css=”.vc_custom_1601902105870{border-top-width: 1px !important;border-right-width: 1px !important;border-bottom-width: 1px !important;border-left-width: 1px !important;}”][vc_column column_width_percent=”100″ position_vertical=”middle” align_horizontal=”align_center” gutter_size=”3″ overlay_alpha=”50″ border_color=”color-465725″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_custom_heading text_color=”color-465725″ text_size=”fontsize-131066″ text_weight=”400″ text_transform=”uppercase” text_height=”fontheight-357766″ uncode_shortcode_id=”701200″ text_color_type=”uncode-palette”]Human Clinical Trials – UNDER DENTIST SUPERVISION<\/p>\n

For Cosmetic Dentistry and Natural Teeth[\/vc_custom_heading][vc_custom_heading text_color=”color-876287″ text_size=”fontsize-132385″ text_weight=”400″ text_height=”fontheight-357766″]THE STUDY IS CARRIED OUT, PROVED AND IN ACCORDANCE WITH THE STANDARDS:<\/strong>
\nRegulation of European Parliament of Council (EC) No. 1223\/2009 of 30 November 2009 on cosmetic products.<\/em>
\nCosmetics Europe – The Personal Care Association (previously COLIPA) Guidelines \u201cProduct Test<\/em>
\nGuidelines for the Assessment of Human Skin Compatibility 1997<\/em>
\nCosmetics Europe – The Personal Care Association (previously COLIPA) Guidelines for the Evaluation of the Efficacy of Cosmetic Products 2008<\/em><\/p>\n

 <\/p>\n

The clinical study was performed over a period of 28 days with a sample of 20 people aged 21 to 67 years and multiple dental problems: yellow teeth, discoloration, caries, dental plaque, dental sensitivity, recent dental cosmetic work (prosthetic works: dental veneers and crowns)[\/vc_custom_heading][vc_custom_heading text_color=”color-465725″ text_size=”fontsize-131066″ text_weight=”400″ text_transform=”uppercase” text_height=”fontheight-357766″]Conclusions and results:[\/vc_custom_heading][vc_custom_heading text_color=”color-876287″ text_size=”fontsize-132385″ text_weight=”400″ text_height=”fontheight-357766″]It was tested under supervision dentist<\/strong> ;<\/p>\n

The results of the tests concluded that the product is very good<\/span> tolerated by all tested subjects, as a result there are no contraindications;<\/p>\n

Confirmed properties of the product following the clinical trial:[\/vc_custom_heading][vc_custom_heading text_color=”color-876287″ text_size=”fontsize-132385″ text_weight=”400″ text_height=”fontheight-357766″]- Cleans teeth efficiently<\/p>\n

– Gently brush your teeth<\/p>\n

– Restores natural white and shine<\/p>\n

– Visibly removes dental plaque<\/p>\n

– Provides a feeling of cleanliness after using the product<\/p>\n

– Refreshes the breath<\/p>\n

– Helps maintain oral hygiene<\/p>\n

– Provides a feeling of freshness<\/p>\n

– Suitable for everyday use[\/vc_custom_heading][\/vc_column][\/vc_row][vc_row unlock_row=”” row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″][vc_column width=”1\/1″][\/vc_column][\/vc_row][vc_row unlock_row=”” row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”2″ column_width_percent=”100″ border_color=”color-465725″ border_style=”solid” shift_y=”0″ z_index=”0″ css=”.vc_custom_1601902105870{border-top-width: 1px !important;border-right-width: 1px !important;border-bottom-width: 1px !important;border-left-width: 1px !important;}”][vc_column column_width_percent=”100″ position_vertical=”middle” align_horizontal=”align_center” gutter_size=”3″ overlay_alpha=”50″ border_color=”color-465725″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_custom_heading text_color=”color-465725″ text_size=”fontsize-131066″ text_weight=”400″ text_transform=”uppercase” text_height=”fontheight-357766″]SAFETY EVALUATION OF PRODUCT[\/vc_custom_heading][vc_custom_heading text_color=”color-876287″ text_size=”fontsize-132385″ text_weight=”400″ text_height=”fontheight-357766″]THE STUDY IS CARRIED OUT, PROVED AND IN ACCORDANCE WITH THE STANDARDS:<\/strong><\/p>\n

Regulation (EC) No 1223\/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products ANNEX I<\/em>[\/vc_custom_heading][\/vc_column][\/vc_row][vc_row unlock_row=”” row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″][vc_column width=”1\/1″][\/vc_column][\/vc_row][vc_row unlock_row=”” row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″][vc_column width=”1\/1″][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row][vc_column][vc_empty_space empty_h=”2″][\/vc_column][\/vc_row][vc_row unlock_row=”” row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ border_color=”color-465725″ border_style=”solid” shift_y=”0″ z_index=”0″ css=”.vc_custom_1601902043111{border-top-width: 1px !important;border-right-width: 1px !important;border-bottom-width: 1px !important;border-left-width: 1px !important;}”][vc_column […]<\/p>\n","protected":false},"author":4,"featured_media":88474,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-88247","page","type-page","status-publish","has-post-thumbnail","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/pranoya.ro\/en\/wp-json\/wp\/v2\/pages\/88247","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pranoya.ro\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pranoya.ro\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pranoya.ro\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/pranoya.ro\/en\/wp-json\/wp\/v2\/comments?post=88247"}],"version-history":[{"count":0,"href":"https:\/\/pranoya.ro\/en\/wp-json\/wp\/v2\/pages\/88247\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pranoya.ro\/en\/wp-json\/wp\/v2\/media\/88474"}],"wp:attachment":[{"href":"https:\/\/pranoya.ro\/en\/wp-json\/wp\/v2\/media?parent=88247"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}